Guide to  

                          the Genetics of

                        Leber's Hereditary 

                   Optic Neuropathy 'LHON'

            A first statement:             Leber's Hereditary Optic Neuropathy (LHON) is a mitochondrial disorder which is possibly due             to mitochondrial mutations causing the enzyme COMPLEX I to be working at 50% of its normal capacity.             A person who carried a LHON mutation may suffer from blindness as the enzyme COMPLEX I fails to provide             enough 'energy' for the neurons in the optic nerves; but what might prevent this failure from happening,             or what might precipitate this failure, remains unknown.

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